Department of Ophthalmology,Kyushu University Hospital

Language

RESEARCH

Hisayama Ophthalmic Epidemiology Group

P.I.;K Fujiwara , E Ueda

The town of Hisayama is a suburb of Fukuoka city in Japan. The population rate increase of Japan from 1960 to 2010 is similar to that of Hisayama. Age distribution was almost the same across all age categories in both 1960 and 2010, similar to that of all of Japan. Moreover, distribution of the labor population was also similar between Japan nationally and Hisayama. Therefore, we can say that Hisayama’s population is a good sample for Japan as a whole.
The Hisayama Study is an ongoing, long-term cohort study on cardiovascular disease and its risk factors in the town of Hisayama. As a part of the overall study, an epidemiologic study of eye disease among residents of the town has been under way since 1998.The purpose of our group is to clarify the prevalence, incidence and risk factors for common ocular disease, which cause visual impairment and vision loss, in a general Japanese population.
We started a new glaucoma incidence study from 2012-2013 in partnership with Oita and Akita universities. Several systemic and environmental factors related with the incidence of glaucoma are expected to be revealed. Furthermore, focusing on the potential of retinal imaging technology leading to early detection and diagnosis of dementia, we conduct to examine the relationship between the retina and the brain, and confirm its utility in community-dwelling elderly.

Selected publications

  1. Prevalence of glaucoma and its systemic risk actors in a General Japanese Population: The Hisayama Study. Fujiwara K, Yasuda M, Hata J, Nakano S, Hashimoto S, Ueda E, Nakamura S, Murakami Y, Nakamuro T, Iwase A, Araie M, Tawara A, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH. Transl Vis Sci Technol. 2022;11:11.
  2. Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study　Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Nakamura S, Hirakawa Y, Higashioka M, Hata J, Ninomiya T, Sonoda KH; Graefes Arch Clin Exp Ophthalmol. 2022/09/24
  3. Association of inner retinal thickness with prevalent dementia and brain atrophy in a general olderly population: the Hisayama Study　Ueda E, Fujiwara K, Hashimoto S, Nakamura S, Sonoda KH; Ophthalmol Sci . 2(2):100157, 2022/04/19
  4. The Ganka-Ekigaku Network (GEN), a network of Japanese ophthalmological epidemiology studies.
    Sasaki M, Miyake M, Fujiwara K, Nanba H, Akiyama M, Yanagi Y, Harada S, Tabara Y, Yasuda M, Yamashita H, Kayama T, Tsubota K, Matsuda F, Hashimoto S, Ueda E, Ninomiya T, Takebayashi T, Tsujikawa A, Sonoda KH, Kawasaki R:
    Cohort Profile: Ophthalmic Epidemiol. 2021 Jun;28(3):237-243.
  5. Five-year incidence of myopic maculopathy in a general Japanese population: the Hisayama Study.JAMA Ophthalmology.
    Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH.
    JAMA Ophthalmol. 2020 Aug 1;138(8):887-893.
  6. Prevalence and Pattern of geographic atrophy in Asia: the Asian Eye Epidemiology Consortium.
    Tyler Hyungtaek R, Kawasaki R, Yih-Chung T, Se Woong K, Paisan R, Mukharram M. B, Miyake M, Jie H, Astrid F, Sasaki M, Vinay N, Charumathi S, Marco Y, Fujiwara K, Raba T, Ian Y W, Kayama T, Shih-Jen C, Tung-Mei K, Yamashita H, Periasamy S, Jonathan C. C, G.H. M. B van R, Sonoda KH, Ya Xing W, Songhomitra Panda-J, Sei H, Ramasamy K, Suganeswari G, Rajiv R, Kenji Y, Timur R.G, Watanee J, Kyu Hyung P, Chui Ming G, Tien Yin W, Ningli W, Jost B.J, Usha C, Ching-Yu C, Yanagi Y Ophthalmology. 2020 Oct;127(10):1371-1381.
    Semin Ophthalmol. 2016 Jul 15:1-5.
  7. Trends in the prevalence of myopia and myopic maculopathy in a Japanese population: the Hisayama Study.
    Ueda E, Hashimoto S, Fujiwara K, Sonoda KH, Yasuda M.
    Invest Ophthalmol Vis Sci. 2019 Jul;1;60(8):2781-86.
  8. Glucose tolerance levels and circumpapillary retinal nerve fiber layer thickness in a general Japanese population: the Hisayama Study.
    Fujiwara K, Yasuda M, Hata J, Hirakawa Y, Hashimoto S, Ueda E, Iwase A, Araie M, Yoshitomi Takeshi, Ninomiya T, Sonoda KH. Am J Ophthalmol.
    2019 Sep;205:140-6.
  9. Association between axial length and myopic maculopathy: the Hisayama Study.
    Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Hata J, Hirakawa Y, Ninomiya T, Sonoda KH.
    Ophthalmology Retina. 2019 Oct;3(10):867-73.
  10. Insulin resistance is a risk factor for increased intraocular pressure: the Hisayama Study. Fujiwara K, Yasuda M, Ninomiya T, Hata J, Hashimoto S, Yoshitomi T, Kiyohara Y, Ishibashi T.
    Invest Ophthalmol Vis Sci. 2015 Dec;56(13):7983-7.
  11. Prevalence and risk factors for myopic retinopathy in a Japanese population: the Hisayama Study.
    Asakuma T, Yasuda M, Ninomiya T, Noda Y, Arakawa S, Hashimoto S, Ohno-Matsui K, Kiyohara Y, Ishibashi T.
    Ophthalmology. 2012 Sep;119(9):1760-5.
  12. Global prevalence and major risk factor of diabetic retinopathy.
    Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, Chen SJ, Dekker JM, Fletcher A, Grauslund J, Haffner S, Hamman RF, Ikram MK, Kayama T, Klein BE, Klein R, Krishnaiah S, Mayurasakorn K, O'Hare JP, Orchard TJ, Porta M, Rema M, RoyMS, Sharma T, Shaw J, Taylor H, Tielsch JM, Varma R, Wang JJ, Wang N, West S, Xu L, Yasuda M, Zhang X, Mitchell P, Wong TY; Meta-Analysis for Eye Disease (META-EYE) Study Group.
    Diabetes Care. 2012 Mar;35(3):556-64.
  13. Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
    Arakawa S, Takahashi A, Ashikawa K, Hosono N, Aoi T, Yasuda M, Oshima Y, Yoshida S, Enaida H, Tsuchihashi T, Mori K, Honda S, Negi A, Arakawa A, Kadonosono K, Kiyohara Y, Kamatani N, Nakamura Y, Ishibashi T, Kubo M .
    Nat Genet. 2011 Sep 11;43(10):1001-4.
  14. Nine-year incidence and risk factors for retinal vein occlusion in a general Japanese population: the Hisayama Study.
    Arakawa S, Yasuda M, Nagata M, Ninomiya T, Hirakawa Y, Doi Y, Kiyohara Y, Ishibashi T.
    Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5905-9.
  15. High serum bilirubin levels and diabetic retinopathy: The Hisayama Study.
    Yasuda M, Kiyohara Y, Hata Y, Arakawa S, Yonemoto K, Doi Y, Iida M, Ishibash T.
    Ophthalmology. 2011 Jul;118(7):1423-8.
  16. Prevalence and systemic risk factors of retinal vein occlusion in a general Japanese population: The Hisayama Study.
    Yasuda M, Kiyohara Y, Hata Y, Arakawa S, Yonemoto K, Doi Y, Iida M, Ishibash T.
    Invest Ophthalmol Vis Sci. 2010 Jun;51(6):3205-9.
  17. Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population: The Hisayama Study.
    Yasuda M, Kiyohara Y, Hata Y, Arakawa S, Yonemoto K, Doi Y, Iida M, Ishibash T.
    Ophthalmology. 2009 Nov;116(11):2135-40.
  18. The five-year incidence and risk factors for age related maculopathy in a general Japanese population: the Hisayama Study.
    Miyazaki M, Kiyohara Y, Yoshida A, Iida M, Nose Y, Ishibash T.
    Invest Ophthalmol Vis Sci. 2005 Jun;46(6):1907-10.
  19. Comparison of diagnostic methods for diabetes mellitus based on prevalence of retinopathy in a Japanese population: The Hisayama Study.
    Miyazaki M, Kubo M, Kiyohara Y, Okubo K, Nakamura H, Fujisawa K, Tokunaga S, Iida M, Nose Y, Ishibashi T.
    Diabetologia. 2004 Aug;47(8):1411-5.