Ocular Tumor and Genomics Group

Ocular Oncology Group

PIs:Mika Tanabe , and Masato Akiyama

Ocular tumor is the life-threatening disease. Our department is one of the specialized institutions for the diagnosis and treatment of ocular tumors in Japan. At Kyushu university hospital, we treat ocular tumors including orbital tumors, lacrimal gland tumors, eyelid tumors, conjunctival tumors, and intraocular tumors. The number of new cases with ocular tumors is about 250 cases per year. As well as the clinical practice, we are conducting basic research.
Recent advantages in genomic analysis expand our understandings of cancer genomes. These studies can provide us with a novel approach for the selection of the treatment drugs, and sub-classifications of the tumors based on molecular level information. Nevertheless, genomic analyses have been performed in a few tumors in the ophthalmologic field. We have started the genomic analysis of the ocular tumors by comprehensive DNA and RNA sequencing using the next-generation sequencer.
We have also launched a new project using the artificial intelligence (AI). Since the majority of the ocular tumors were rare, the diagnosis of ocular tumor is not easy for the family doctors and general ophthalmologists. Now, our department have the computational server which contains graphic processing units (GPU) in order to develop a deep learning system for the precise diagnosis of ocular tumors.

Selected publications

1. High-risk HPV-related Squamous Cell Carcinoma in the Conjunctiva and Lacrimal sac: Clinicopathologic Characteristics and Diagnostic Utility of p16 and Rb Immunohistochemistry　Hongo T, Yamamoto H, Tanabe M, Yasumatsu R, Kuga R, Miyazaki Y, Jiromaru R, Hashimoto K, Tateishi Y, Sonoda KH, Nakagawa T, Oda Y; Am J Surg Pathol. 46(7):977-987, 2022/07/01
2. Two Cases of Angiosarcoma with Persistent Unilateral Eyelid Swellinga
   Sakisaka S, Tanabe M, Imayama S, Zeze N, Yamana K, Yoshikawa H, Sonoda KH;a
   Ocular Oncology and Pathology 8(1):16-21, 2022/02/01
3. Defining High-Risk Retinoblastoma: A Multicenter Global Survey　 Swathi K, Carol L S, Nathalie C, Francis LM, Guillermo C, Hans EG, Yoshikawa H, Ido Didi F, Jesse LB, John DM, Kahaki K, M Ashwin R, Manoj P, Tanabe M, Furuta M, Natalia G, Patricia Chevez-Barrios, Patricia S, Ralph CE Jr, Riffat R, Rosdali Díaz C, Sadia S, Sandra S, Shahar F, Suzuki S, Tatiana LU, Xunda Ji;
   JAMA ophthalmology. 140(1):30-36, 2022/01/01
4. Alveolar soft part sarcoma of the orbit: A case report Oda T, Kikuchi K, Togao O, Baba S, Mizoguchi M, Tanabe M, Itoiu M, Yamamoto H, Ishigami K, Hiwatashi A;
   Radiology Case reports. 16:3766-3771, 2021/09/05
5. A case of primary orbital solitary fibrous tumor with lung metastases 41 years after initial treatment
   Tanabe M, Yoshikawa H, Yuichi Yamada, Yoshinao Oda, Sonoda KH;
   Orbit. 10:1-5, 2021/07/14
6. Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma.
   Ueda T, Koga Y, Yoshikawa H, Tanabe M, Yamana K, Oba U, Nakashima K, Ono H, Ichimura T, Hasegawa S, Kato W, Kobayashi T, Nakayama H , Sakai Y, Yoshitake T, Ohga S, Oda Y, Suzuki S, Sonoda KH, Ohga S
   BMC Pediatr. 2020 Jan 28;20(1):37,
7. Cataracts after Low-Dose Radiotherapy for Lymphoproliferative Disease of the Ocular Adnexa.
   Hashimoto S, Yoshikawa H, Miyagi M, Onishi Y, Ohga S, Asai K, Ishibashi T.
   Semin Ophthalmol. 2016 Jul 15:1-5.
8. Clinical Features of Systemic Metastatic Retinal Lymphoma in Japanese Patients.
   Taki R, Takeda A, Yoshikawa H, Fukuhara T, Arita R, Suehiro Y, Choi I, Kumano Y, Nakamura T, Ishibashi T.
   Ocul Immunol Inflamm. 2016 Apr 12:1-9.
9. Distinct Profiles of Soluble Cytokine Receptors Between B-Cell Vitreoretinal Lymphoma and Uveitis.
   Takeda A, Yoshikawa H, Fukuhara T, Hikita S, Hijioka K, Otomo T, Arita R, Hisatomi T, Kimura K, Yoshida S, Kawano Y, Sonoda KH, Ishibashi T.
   Invest Ophthalmol Vis Sci. 2015 Nov;56(12):7516-23. doi: 10.1167/iovs.15-17465.
10. Ocular surface squamous neoplasia: analysis of 34 cases.
    Tanabe M, Yoshikawa H, Onishi Y, Kohno R, Ishibashi T.
    Nippon Ganka Gakkai Zasshi. 2014 May;118(5):425-32. Japanese.
11. A case of Muir-Torre syndrome with multiple cancers of bilateral eyelids and breast.
    Kamisasanuki T, Uchino E, Fukushima J, Yoshikawa H, Ishibashi T, Sakamoto T.
    Korean J Ophthalmol. 2013 Jun;27(3):204-7. doi: 10.3341/kjo.2013.27.3.204.
12. A case of metastatic choroidal tumor simulating a choroidal melanoma.
    Arima M, Yoshikawa H, Kagimoto T, Kohno R, Ishibashi T.
    Jpn J Ophthalmol. 2011 May;55(3):312-4. doi: 10.1007/s10384-011-0015-5.
13. Congenital simple hamartoma of the retinal pigment epithelium in an Asian.
    Gotoh M, Yoshikawa H, Kagimoto HT, Ishibashi T.
    Jpn J Ophthalmol. 2008 Mar-Apr;52(2):144-5. doi: 10.1007/s10384-008-0509-y.
14. Retinal capillary hemangioma managed by transpupillary thermotherapy.
    Mochizuki Y, Noda Y, Enaida H, Hata Y, Ueno A, Yoshikawa H, Ishibashi T.
    Retina. 2004 Dec;24(6):981-4.
15. Bilateral epiretinal membranes in nevoid basal cell carcinoma syndrome.
    Yoshida S, Yoshikawa H, Yoshida A, Nakamura T, Noda Y, Gondoh H, Fukagawa S, Moroi Y, Urabe K, Furue M, Ishibashi T.
    Acta Ophthalmol Scand. 2004 Aug;82(4):488-90.
16. Conjunctival keratoacanthoma in an Asian.
    Kifuku K, Yoshikawa H, Sonoda KH, Kawano Y, Miyazaki K, Ishibashi T.
    Arch Ophthalmol. 2003 Jan;121(1):118-9.